Henry Cavill's confirmed that he'd be willing to appear in a Mass Effect TV series, providing it's handled well. Speaking to GamesRadar for a recent interview, The Witcher and Superman actor confirmed he's up for starring up in a live-action series.
Advising he'd look at how flexible that adaptation is, Cavill elaborated further, confirming:
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Henry Cavill “Would Love” to Star in a Mass Effect TV Series
As part of this conversation, Cavill confirmed he enjoyed the original Mass Effect trilogy, explaining:

We've recently seen rumours that Amazon's planning an adaptation - which led to a former Mass Effect writer stating the idea "makes me cringe. - and Cavill himself stirred rumours via an Instagram post (as seen above) in February. According to Deadline, Amazon's close to sealing a deal with EA and should that push through, we could see Cavill joining.